Kedu ihe 5 Amino 1MQ na-eme?
Ngwakọta 5-Amino-1MQ , nke dị obere, nke a na-ahọrọ nke ọma, ma nwee ike ịgafe akpụkpọ ahụ sel, na-achọ imetụta sistemụ sel ụfọdụ nke na-achịkwa nchekwa abụba, uto akwara, na metabolism. Ndị ọkà mmụta sayensị buru ụzọ mepụta 5-Amino-1MQ iji mụọ ụzọ metabolic nke jikọtara ya na oke ibu na nsogbu metabolic metụtara afọ.
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Nkowa Obere
"5-Amino-1MQ (NNMTi)" bụ peptide nke nwere ike ime ka ike nke anụ ahụ dịkwuo mma ma dị irè maka ọkụ ọkụ na abụba abụba. Ihe kpatara "5-Amino-1MQ" ji dị irè maka iri nri bụ na ọ nwere ike ịbawanye ntinye nke NAD (nicotinamide adenine dinucleotide), na NAD bụ ihe dị mkpa maka ịnọgide na-enwe ahụ ike na ọrụ n'ime ahụ. NNMTi bụ ihe mgbochi dị irè nke nicotinamide N-methyltransferase (NNMT) (IC50=1.2μM), ma nwee ike ịhọrọ ya na-ejikọta ya na ihe fọdụrụ na saịtị NNMT na-ejikọta ya. NNMTi nwere ike ịkwalite ọdịiche nke myoblasts na vitro ma welie njikọ na ike mmeghari nke mkpụrụ ndụ sel anụ ahụ na ụmụ oke agadi.
Ebe agbaze : 213-214°C
Usoro ihe omimi: C10H11IN2
Onu ogugu oke: 286.11
Usoro nkwadebe
5-Amino-1Mq bụ obere ihe mgbochi molecule nke nicotinamide N-methyltransferase (NNMT), nke a na-amụ n'ọtụtụ ebe n'afọ ndị na-adịbeghị anya. Banyere nkwadebe nke ihe a, e nwere ụzọ abụọ sịntetik a kpọtụrụ aha na akwụkwọ ugbu a: Otu bụ mmeghachi omume kpọmkwem nke 5-Aminoquinoline na Iodometane na mmanya Isopropyl. Mwepu nke mmeghachi omume a bụ obere mkpụrụ. Onye ọzọ bụ mmeghachi omume nke 5-Aminoquinoline na Iodomethane iji mepụta 5-Amino-1Mq, nke a na-enweta site na mbelata na ntụ ntụ ígwè. Mwepu nke mmeghachi omume a bụ na mwepu ngwaahịa ahụ siri ike, na oke mmiri na-ekpofu ihe dị ukwuu, na-akpata mmetọ gburugburu ebe obibi dị njọ. Ya mere, ọ dị mkpa karịsịa ịchọpụta usoro mmepụta ihe nke na-acha akwụkwọ ndụ akwụkwọ ndụ, enyi na gburugburu ebe obibi, dị mfe iji rụọ ọrụ, akụ na ụba na nchekwa.
N'ihi adịghị ike nke nkà na ụzụ dị ugbu a, ihe mmepụta ihe dị ugbu a na-enye usoro nhazi nke 5-Amino-1Mq, gụnyere usoro ndị a: Tinye 5-Aminoquinoline na ihe mgbaze mmeghachi omume na reactor na kpalie; Gbanyụọ Iodomethane n'ime ihe mgbaze mmeghachi omume, tinye ya n'okirikiri na reactor. Mgbe agbakwunyere dropwise, mee ka okpomọkụ dịkwuo elu ma nọgide na-enwe okpomọkụ nke mmeghachi omume, wee dị jụụ ma nọgide na-akpali akpali, nyochaa, ma kpochaa achicha nzacha na obere ihe mgbaze mmeghachi omume. Mgbe emechara achicha nzacha, a na-asa ya ma kpoo ya ka o wee nweta ihe siri ike na-acha ọbara ọbara. N'ime mmepụta ihe a, e nwetara ngwaahịa e lekwasịrị anya site na mmeghachi omume ozugbo nke 5-Aminoquinoline na Iodometane. Site n'ịkwalite ọnọdụ mmeghachi omume, ọdịnaya nke ngwaahịa ezubere iche na usoro mmeghachi omume na-abawanye, na-enyocha ọnọdụ ịdị ọcha nke ngwaahịa ahụ. Mee ka ịdị ọcha nke 5-Amino-1Mq nwee ike iru karịa 99%.
Nnyocha metụtara ya
Oke ibu bụ nsogbu ahụike zuru ụwa ọnụ ma na-akawanye njọ, yana ụzọ ọgwụgwọ ole na ole dị irè. Ọmụmụ ihe ahụ nyochara uru metabolic na physiological nke nchikota nke 5-Amino-1Mq (NNMTi) ọgwụgwọ na nnọchi nri na oke oke ibu na-ebute nri. Tụnyere naanị imezi nri, 5-Amino-1Mq ọgwụgwọ jikọtara ya na nri nnọchi nwere ike mee ngwangwa ma melite ibu na abụba ọnwụ, dịkwuo ruru nke dabere ozu uka ka ahu arọ, ibelata arọ nke ọcha adipose anụ ahụ na imeju na epididymis, belata imeju ibu ibu, na melite imeju steatosis site onye nnọchi. N'ụzọ dị mkpa, nchikota nke abụọ nwere ike normalize ahụ mejupụtara na imeju oke ibu kwa. 5-Amino-1Mq ọgwụgwọ arụpụtala pụrụ iche metabolomic e ji mara na adipose anụ ahụ, tumadi na-abawanye ụba nke ketogenic amino asịd na mgbanwe metabolites metụtara ike metabolism ụzọ. N'ihe niile, ụkpụrụ nke ịdị arọ ahụ, oke ibu, imeju physiology na adipose tissue metabolome site na ọgwụgwọ 5-Amino-1Mq na-akwado ya dị ka usoro ọgwụgwọ na-ekwe nkwa maka oke ibu na nsogbu ndị na-ebute oke ibu.
Ọzọkwa, 5-Amino-1Mq (NNMTi) nwekwara ike ime ka ike dịkwuo elu ma kwalite ike ịmaliteghachi akwara ịka nká, si otú a na-enye usoro ọgwụgwọ na-ekwe nkwa maka sarcopenia. Nnyocha egosiwo na ọgwụgwọ 5-Amino-1Mq nwere ike ọ bụghị naanị ịkwalite mmụba nke ọdịnaya lipid na mkpụrụ ndụ akwara, mana ọ na-abawanye ụbara akwara gastrocnemius mgbe ejikọtara ya na mmega ahụ. Ọgwụ ndị dabeere na 5-Amino-1Mq, ma ọ bụ naanị ya ma ọ bụ na-ejikọta ya na mmega ahụ, ga-aba uru maka ọgwụgwọ nke sarcopenia na ọrịa dị iche iche metụtara afọ.
Kedu ihe bụ mgbakwunye amino 1MQ 5?
5-Amino-1MQ bụ obere molekul nwere ikike dị ukwuu na ngalaba ahụike na ịdị mma. A na-ekewa ya dị ka ihe mmepụta nke methylquinolinium. Ngwakọta peptide a pụrụ iche enwetala nlebara anya maka ọrụ ya n'ịkwado metabolism, njikwa ibu, na mmepụta ike cell.
Enwere mmetụta 5 Amino 1MQ?
Enwere mmetụta dị n'akụkụ? Ọgwụ ọ bụla nwere ike inwe mmetụta dị n'akụkụ, mana nke 5 Amino 1MQ dị ntakịrị. Ihe nfụkasị ahụ ma ọ bụ ihe nfụkasị ahụ ga-ekwe omume na peptide a.
1. Ị na-enwe nsogbu nnyefe n'ala m?
A: Anyị nwere ụlọ nkwakọba ihe na Europe, America na Australia. N'otu oge ahụ, ọ bụrụ na ị si Europe, ngwaahịa nwere ike izipu si Germany, na ọ bụrụ na ị si America ma ọ bụ Canada, ngwaahịa nwere ike iziga si California.
2. Kedu ka esi achịkọta ngwongwo ndị ahụ?
A: Anyị na-ezigakarị ngwongwo na ngwugwu ngbanwe n'èzí na akpa transperent nke okpukpu abụọ nke oyi akwa n'ime. Anyị anwalela puku ụzọ ngwugwu, ọ na-ele anya dị njọ na akọ.
3. Kedu mgbe ị ga-ezipụ ngwongwo ndị ahụ mgbe ịkwụ ụgwọ gara nke ọma?
A: Nọmalị ka a ga-enyefe n'ime 2-3 ụbọchị mgbe iwu kwadoro, ma e wezụga ngwaahịa ahaziri.
4. Kedu ka esi aga n'ihu n'usoro?
A: Biko, ka m konw ngwaahịa ị na-achọ, ọnụ ọgụgụ na ebe mba wihch na-enyere m aka inye gị a ziri ezi price; Mgbe ị na-akwado niile nkọwa nke iji, kwụọ ụgwọ ego n'ihu ma nye anyị Mbupu adreesị. Anyị na-ahazi Mbupu na mbụ mgbe natara ugwo na-enye mgbe-ahịa ọrụ mgbe ị na-enweta ngwugwu.
Zipu ajụjụ gị maka nkọwa ndị ọzọ, pịa email: sales4@faithfulbio.com
